Article
Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes.
Nature biotechnology - 1 Nov 2015
Shukla Sachet A, Rooney Michael S, Rajasagi Mohini, Tiao Grace, Dixon Philip M, Lawrence Michael S, Stevens Jonathan, Lane William J, Dellagatta Jamie L, Steelman Scott, Sougnez Carrie, Cibulskis Kristian, Kiezun Adam, Hacohen Nir, Brusic Vladimir, Wu Catherine J, Getz Gad
Abstract excerpt
Detection of somatic mutations in human leukocyte antigen (HLA) genes using whole-exome sequencing (WES) is hampered by the high polymorphism of the HLA loci, which prevents alignment of sequencing reads to the human reference genome. We describe a computational pipeline that enables accurate inference of germline alleles of class I HLA-A, B and C genes and subsequent detection of mutations in these genes using...
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