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Article

Concordance between predicted HLA type using next generation sequencing data generated for non-HLA purposes and clinical HLA type.

Human immunology - 1 Aug 2020

Moyer Ann M, Dukek Brian, Duellman Patti, Schneider Brittany, Wakefield Laurie, Skierka Jennifer M, Avula Rajeswari, Bhagwate Aditya V, Kalari Krishna R, Kreuter Justin D, Goetz Matthew P, Boughey Judy C, Black John L, Gandhi Manish J

Abstract excerpt

We explored the feasibility of obtaining accurate HLA type using pre-existing NGS data not generated for HLA purposes. 83 exomes and 500 targeted NGS pharmacogenomic panels were analyzed using Omixon HLA Explore, OptiType, and/or HLA-Genotyper software. Results were compared against clinical HLA genotyping. 765 (94.2%) Omixon and 769 (94.7%) HLA-Genotyper of 812 germline allele calls across class I/II loci and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32546429
DOI: 10.1016/j.humimm.2020.06.002
PMCID: PMC7721171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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