Article
An Automated Toolbox to Predict Single Subject Atrophy in Presymptomatic Granulin Mutation Carriers.
Journal of Alzheimer's disease : JAD - 1 Jan 2022
Premi Enrico, Costa Tommaso, Gazzina Stefano, Benussi Alberto, Cauda Franco, Gasparotti Roberto, Archetti Silvana, Alberici Antonella, van Swieten John C, Sanchez-Valle Raquel, Moreno Fermin, Santana Isabel, Laforce Robert, Ducharme Simon, Graff Caroline, Galimberti Daniela, Masellis Mario, Tartaglia Carmela, Rowe James B, Finger Elizabeth, Tagliavini Fabrizio, de Mendonça Alexandre, Vandenberghe Rik, Gerhard Alexander, Butler Chris R, Danek Adrian, Synofzik Matthis, Levin Johannes, Otto Markus, Ghidoni Roberta, Frisoni Giovanni, Sorbi Sandro, Peakman Georgia, Todd Emily, Bocchetta Martina, Rohrer Johnathan D, Borroni Barbara
Abstract excerpt
BACKGROUND: Magnetic resonance imaging (MRI) measures may be used as outcome markers in frontotemporal dementia (FTD). OBJECTIVES: To predict MRI cortical thickness (CT) at follow-up at the single subject level, using brain MRI acquired at baseline in preclinical FTD. METHODS: 84 presymptomatic subjects carrying Granulin mutations underwent MRI scans at baseline and at follow-up (31.2±16.5 months). Multivariate...
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