Modelling the cascade of biomarker changes in GRN-related frontotemporal dementia.

doi:10.1136/jnnp-2020-323541

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Article

Modelling the cascade of biomarker changes in GRN-related frontotemporal dementia.

Journal of neurology, neurosurgery, and psychiatry - 1 May 2021

Panman Jessica L, Venkatraghavan Vikram, van der Ende Emma L, Steketee Rebecca M E, Jiskoot Lize C, Poos Jackie M, Dopper Elise G P, Meeter Lieke H H, Donker Kaat Laura, Rombouts Serge A R B, Vernooij Meike W, Kievit Anneke J A, Premi Enrico, Cosseddu Maura, Bonomi Elisa, Olives Jaume, Rohrer Jonathan D, Sánchez-Valle Raquel, Borroni Barbara, Bron Esther E, Van Swieten John C, Papma Janne M, Klein Stefan

Abstract excerpt

OBJECTIVE: Progranulin-related frontotemporal dementia (FTD-GRN) is a fast progressive disease. Modelling the cascade of multimodal biomarker changes aids in understanding the aetiology of this disease and enables monitoring of individual mutation carriers. In this cross-sectional study, we estimated the temporal cascade of biomarker changes for FTD-GRN, in a data-driven way. METHODS: We included 56...

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PMID: 33452053
DOI: 10.1136/jnnp-2020-323541
PMCID: PMC8053353

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