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Article

Pattern of structural and functional brain abnormalities in asymptomatic granulin mutation carriers.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Oct 2014

Pievani Michela, Paternicò Donata, Benussi Luisa, Binetti Giuliano, Orlandini Alberto, Cobelli Milena, Magnaldi Silvia, Ghidoni Roberta, Frisoni Giovanni B

Abstract excerpt

BACKGROUND: To investigate the patterns of brain atrophy, white matter (WM) tract changes, and functional connectivity (FC) abnormalities in asymptomatic granulin (GRN) mutation carriers. METHODS: Ten cognitively normal subjects (five mutation carriers, GRN+; years to estimated disease onset: 12±7; five mutation noncarriers, GRN-) underwent a clinical and imaging (structural, diffusion tensor, and resting-state...

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Identifiers

PMID: 24418059
DOI: 10.1016/j.jalz.2013.09.009

Genes

GRN

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