Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Granulin mutation drives brain damage and reorganization from preclinical to symptomatic FTLD.

Neurobiology of aging - 1 Oct 2012

Borroni Barbara, Alberici Antonella, Cercignani Mara, Premi Enrico, Serra Laura, Cerini Carlo, Cosseddu Maura, Pettenati Carla, Turla Marinella, Archetti Silvana, Gasparotti Roberto, Caltagirone Carlo, Padovani Alessandro, Bozzali Marco

Abstract excerpt

Granulin (GRN) mutations have been identified as a major cause of frontotemporal lobar degeneration (FTLD) by haploinsufficiency mechanism, although their effects on brain tissue dysfunction and damage still remain to be clarified. In this study, we investigated the pattern of neuroimaging abnorm...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Aged
Share to Frontotemporal Lobar Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intercellular Signaling Peptides and Proteins

Share to Magnetic Resonance Imaging

Share to Nerve Net

Share to Neuronal Plasticity

Share to Progranulins

Source

Identifiers

PMID: 22130207
DOI: 10.1016/j.neurobiolaging.2011.10.031

Genes

GRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22130207-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Granulin mutation drives brain damage and reorganization from preclinical to symptomatic FTLD.PMID 22130207Read ↗

Multimodal FMRI resting-state functional connectivity in granulin mutations: the case of fronto-parietal dementia.Semantic proximity Read ↗

The neuroimaging signature of frontotemporal lobar degeneration associated with Granulin mutations: an effective connectivity study.Semantic proximity Read ↗

Looking for Neuroimaging Markers in Frontotemporal Lobar Degeneration Clinical Trials: A Multi-Voxel Pattern Analysis Study in Granulin Disease.Semantic proximity Read ↗

Disease-related cortical thinning in presymptomatic granulin mutation carriers.Semantic proximity Read ↗

Pattern of structural and functional brain abnormalities in asymptomatic granulin mutation carriers.Semantic proximity Read ↗

Gray matter changes in asymptomatic C9orf72 and GRN mutation carriersSemantic proximity Read ↗

Effect of TMEM106B polymorphism on functional network connectivity in asymptomatic GRN mutation carriers.Semantic proximity Read ↗

White matter hyperintensities characterize monogenic frontotemporal dementia with granulin mutations.Semantic proximity Read ↗

Neuroanatomical Correlates of Transcranial Magnetic Stimulation in Presymptomatic Granulin Mutation Carriers.Semantic proximity Read ↗

Molecular signature of disease onset in granulin mutation carriers: a gene expression analysis study.Semantic proximity Read ↗

Network degeneration and dysfunction in presymptomatic C9ORF72 expansion carriersSemantic proximity Read ↗

Patterns of gray matter atrophy in genetic frontotemporal dementia: results from the GENFI study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.