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Article

Pre-symptomatic radiological changes in frontotemporal dementia: propagation characteristics, predictive value and implications for clinical trials.

Brain imaging and behavior - 1 Dec 2022

McKenna Mary Clare, Lope Jasmin, Tan Ee Ling, Bede Peter

Abstract excerpt

Computational imaging and quantitative biomarkers offer invaluable insights in the pre-symptomatic phase of neurodegenerative conditions several years before clinical manifestation. In recent years, there has been a focused effort to characterize pre-symptomatic cerebral changes in familial frontotemporal dementias using computational imaging. Accordingly, a systematic literature review was conducted of original...

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PMID: 35920960
DOI: 10.1007/s11682-022-00711-z
PMCID: PMC9712335

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