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Article

The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy.

Molecular neurobiology - 1 Sept 2016

Zhang Cheng-Cheng, Xing Ang, Tan Meng-Shan, Tan Lan, Yu Jin-Tai

Abstract excerpt

Microtubule-associated protein tau (MAPT) is a gene responsible for encoding tau protein, which is tightly implicated in keeping the function of microtubules and axonal transport. Hyperphosphorylated tau protein participates in the formation of neurofibrillary tangles (NFTs), which characterize many neurodegenerative disorders termed tauopathies. Genome-wide association studies (GWAS) have demonstrated numerous...

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Source

Identifiers

PMID: 26363795
DOI: 10.1007/s12035-015-9415-8

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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