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Targeting Histone Deacetylases: Opportunities for Cancer Treatment and Chemoprevention

16 Jan 2022

Abstract excerpt

The dysregulation of gene expression is a critical event involved in all steps of tumorigenesis. Aberrant histone and non-histone acetylation modifications of gene expression due to the abnormal activation of histone deacetylases (HDAC) have been reported in hematologic and solid types of cancer. In this sense, the cancer-associated epigenetic alterations are promising targets for anticancer therapy and...

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PMID: 35057104
DOI: 10.3390/pharmaceutics14010209

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