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Targeting histone deacetylases for the treatment of cancer and inflammatory diseases

25 Sept 2006

Abstract excerpt

Histone deacetylases (HDACs) are involved in chromatin remodeling and modification of nonhistone transcription regulatory proteins, thus modulating the expression of genes important for complex biological events. Dysregulation of HDACs and aberrant chromatin acetylation and deacetylation may be implicated in the pathogenesis of various diseases, including cancer and inflammatory diseases. A significant number of...

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PMID: 17001696
DOI: 10.1002/jcp.20781

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