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Article

Histone-Deacetylase Inhibitors for the Treatment of Cancer

1 Jun 2004

Abstract excerpt

Histone deacetylase inhibitors (HDACi) are a promising new class of chemotherapeutic drug currently in early phase clinical trials. A large number of structurally diverse HDACi have been purified or synthesised that mostly inhibit the activity of all eleven class I and II HDACs. While these agents demonstrate many features required for anti-cancer activity such as low toxicity against normal cells and an ability...

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PMID: 15153801
DOI: 10.4161/cc.3.6.927

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