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Article

Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy.

Nutrients - 6 Jun 2018

Singh Amit Kumar, Bishayee Anupam, Pandey Abhay K

Abstract excerpt

Cancer initiation and progression are the result of genetic and/or epigenetic alterations. Acetylation-mediated histone/non-histone protein modification plays an important role in the epigenetic regulation of gene expression. Histone modification is controlled by the balance between histone acetyltransferase and (HAT) and histone deacetylase (HDAC) enzymes. Imbalance between the activities of these two enzymes is...

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Identifiers

PMID: 29882797
DOI: 10.3390/nu10060731
PMCID: PMC6024317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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