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Medicinal chemistry advances in targeting class I histone deacetylases

31 Aug 2023

Abstract excerpt

Histone deacetylases (HDACs) are a class of zinc (Zn)-dependent metalloenzymes that are responsible for epigenetic modifications. HDACs are largely associated with histone proteins that regulate gene expression at the DNA level. This tight regulation is controlled by acetylation [via histone acetyl transferases (HATs)] and deacetylation (via HDACs) of histone and non-histone proteins that alter the coiling state...

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PMID: 37711592
DOI: 10.37349/etat.2023.00166

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