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Article

Histone deacetylase inhibitors in cancer therapy. A review

21 Nov 2013

Abstract excerpt

BACKGROUND: Despite recent success toward discovery of more effective anticancer drugs, chemoresistance remains a major cause of treatment failure. There is emerging evidence that epigenetics plays a key role in the development of the resistance. Epigenetic regulators such as histone acetyltransferases (HATs) and histone deacetylases (HDACs) play an important role in gene expression. The latter are found to be...

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PMID: 24263215
DOI: 10.5507/bp.2013.085

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