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Recent advances in class IIa histone deacetylases research

6 Sept 2019

Abstract excerpt

Epigenetic control plays an important role in gene regulation through chemical modifications of DNA and post-translational modifications of histones. An essential post-translational modification is the histone acetylation/deacetylation-process which is regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs). The mammalian zinc dependent HDAC family is subdivided into three classes: class I...

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PMID: 31561937
DOI: 10.1016/j.bmc.2019.115087

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