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Role of histone deacetylase inhibitors in non-neoplastic diseases

1 Jul 2024

Abstract excerpt

Background: Epigenetic dysregulation has been implicated in the development and progression of a variety of human diseases, but epigenetic changes are reversible, and epigenetic enzymes and regulatory proteins can be targeted using small molecules. Histone deacetylase inhibitors (HDACis), as a class of epigenetic drugs, are widely used to treat various cancers and other diseases involving abnormal gene...

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PMID: 39071622
DOI: 10.1016/j.heliyon.2024.e33997

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