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Article

Generation and Application of Inducible Chimeric RNA ASTN2-PAPPAas Knockin Mouse Model.

Cells - 14 Jan 2022

Luo Yichen, Du Liang, Yao Zhimeng, Liu Fan, Li Kai, Li Feifei, Zhu Jianlin, Coppes Robert P, Zhang Dianzheng, Pan Yunlong, Gao Shegan, Zhang Hao

Abstract excerpt

Chimeric RNAs (chiRNAs) play many previously unrecognized roles in different diseases including cancer. They can not only be used as biomarkers for diagnosis and prognosis of various diseases but also serve as potential therapeutic targets. In order to better understand the roles of chiRNAs in pathogenesis, we inserted human sequences into mouse genome and established a knockin mouse model of the...

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Identifiers

PMID: 35053393
DOI: 10.3390/cells11020277
PMCID: PMC8773765

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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