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Article

PIK3CA and p53 Mutations Promote 4NQO-Initated Head and Neck Tumor Progression and Metastasis in Mice.

Molecular cancer research : MCR - 1 Jun 2020

García-Carracedo Darío, Cai Yi, Qiu Wanglong, Saeki Kiyoshi, Friedman Richard A, Lee Andrew, Li Yinglu, Goldberg Elizabeth M, Stratikopoulos Elias E, Parsons Ramon, Lu Chao, Efstratiadis Argiris, Philipone Elizabeth M, Yoon Angela J, Su Gloria H

Abstract excerpt

The PI3K signaling pathway is frequently mutated in head and neck squamous cell carcinoma (HNSCC), often via gain-of-function (GOF) mutations in the PIK3CA gene. Here, we present novel genetically engineered mouse models (GEMM) carrying a GOF allele Loxp-STOP-Loxp(LSL)-PIK3CAH1047R (E20) alone or in combination with heterozygous LSL-p53+/R172H (p53) mutation with tissue-specific expression to interrogate the role...

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Identifiers

PMID: 32152233
DOI: 10.1158/1541-7786.MCR-19-0549
PMCID: PMC7272268

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