Article
p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer.
Molecular cancer research : MCR - 1 Jun 2006
Zhang Zhongqiu, Wang Yian, Yao Ruisheng, Li Jie, Lubet Ronald A, You Ming
Abstract excerpt
In this study, we did a bioassay employing mice with a dominant-negative p53 mutation (p53(Val135/WT)) to assess whether a germ-line p53 mutation predisposed mice toward the development of squamous cell carcinomas (SCC) in the oral cavity. Treatment of the mouse oral cavity with 4-nitroquinoline-1-oxide produced a 66%, 91%, and 20% tumor incidence in the oral cavity, esophagus, and forestomach/stomach,...
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