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Article

Construction and evaluation of an independently generated transgenic mouse model carrying mutated human HRAS genes for short-term carcinogenicity assessment.

Transgenic research - 3 Sept 2026

Zeng Wen, Zhang Yanlin, Yang Xiaoliu, Li Xiaoyu, Jiang Yunlong, Jia Dongjing, Liang Juan, Wang Tao

Abstract excerpt

The study aimed to construct and evaluate an independently generated transgenic mouse model applied to the short-term carcinogenicity assessment. Mutated human HRAS fragment containing an intron point-mutation was inserted into C57BL/6JGpt mice via bacterial artificial chromosome transgenic technology, eventually generating BALB/c;B6J-Tg(hHRAS)16/Gpt mice, abbreviated as HRAS mice. The inserted human HRAS...

Read the complete abstract on PubMed

Topics

Animals
Mice, Transgenic
Humans
Mice
Proto-Oncogene Proteins p21(ras)
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Methylnitrosourea

Carcinogenicity Tests

Mutation

Mice, Inbred C57BL

Disease Models, Animal

Carcinogens

Mice, Inbred BALB C

Chromosomes, Artificial, Bacterial

Source

Identifiers

PMID: 42690476
DOI: 10.1007/s11248-026-00510-y

Genes

HRAS
MKI67

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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