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Large-Scale Functional Genomics Screen to Identify Modulators of Human β-Cell Insulin Secretion

4 Jan 2022

Abstract excerpt

Type 2 diabetes (T2D) is a chronic metabolic disorder affecting almost half a billion people worldwide. Impaired function of pancreatic β-cells is both a hallmark of T2D and an underlying factor in the pathophysiology of the disease. Understanding the cellular mechanisms regulating appropriate insulin secretion has been of long-standing interest in the scientific and clinical communities. To identify novel genes...

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PMID: 35052782
DOI: 10.3390/biomedicines10010103

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