Article

Functional, transcriptomic, and proteomic profiles of human primary and stem cell-derived beta cells in a state of high insulin production and increased fragility

2026-08-11

Abstract excerpt

Insulin production is a cardinal feature of pancreatic β cells. Studies in rodents show that β cells can switch between low and high insulin gene activity states and that elevated insulin production makes β cells more vulnerable to stresses associated with diabetes. In people, genetically elevated insulin production increases the risk of type 1 diabetes. Via effects on obesity, hyperinsulinemia contributes to the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c33c75da-77d5-5e21-a3d3-1b5d84cf2505
DOI: 10.64898/2026.08.05.742945

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Functional, transcriptomic, and proteomic profiles of human primary and stem cell-derived beta cells in a state of high insulin production and increased fragilityDOI 10.64898/2026.08.05.742945Read

Characterization of the secretome, transcriptome and proteome of human β cell line EndoC-βH1Semantic proximity Read

Integrated meta-analysis of public human pancreatic single-cell transcriptomes reveals distinct beta-cell state trajectories across aging and diabetesSemantic proximity Read

Identification of unique cell type responses in pancreatic islets to stressSemantic proximity Read

Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after TransplantationSemantic proximity Read

Proteomic predictors of individualized nutrient-specific insulin secretion in health and diseaseSemantic proximity Read

Progressive endoplasmic reticulum stress over time due to human insulin gene mutation contributes to pancreatic beta cell dysfunction.Semantic proximity Read

A transcriptional cross species map of pancreatic islet cellsSemantic proximity Read

Dynamic <i>Ins2</i> gene activity defines β-cell maturity statesSemantic proximity Read

The quest to make fully functional human pancreatic beta cells from embryonic stem cells: climbing a mountain in the clouds.Semantic proximity Read

Dynamic Ins2 Gene Activity Defines β-Cell Maturity StatesSemantic proximity Read

Interrogating islets in health and disease with single-cell technologiesSemantic proximity Read

Insulin demand regulates β cell number via the unfolded protein responseSemantic proximity Read