Article

High-throughput quantitative screening of glucose-stimulated insulin secretion and insulin content using automated MALDI-TOF mass spectrometry

2023-02-15

Abstract excerpt

Type 2 diabetes (T2D) is a metabolic disorder characterized by loss of pancreatic β- cell function, decreased insulin secretion and increased insulin resistance, that affects more than 400 million people worldwide. Although several treatments are proposed to patients suffering from T2D, long-term control of glycemia remains a challenge. Therefore, identifying new potential drugs and targets that positively affect...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7d983f12-58b3-5806-a13b-f2b9fd1aa722
DOI: 10.1101/2023.02.14.528514

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High-throughput quantitative screening of glucose-stimulated insulin secretion and insulin content using automated MALDI-TOF mass spectrometryDOI 10.1101/2023.02.14.528514Read

Large-Scale Functional Genomics Screen to Identify Modulators of Human β-Cell Insulin SecretionSemantic proximity Read

An siRNA Screen in Pancreatic Beta Cells Reveals a Role for Gpr27 in Insulin ProductionSemantic proximity Read

An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturationSemantic proximity Read

Glucose-dependent miR-125b is a negative regulator of β-cell functionSemantic proximity Read

Recovery of human type 2 diabetes beta cell function associates with transcriptomic signatures that point to novel therapeutic targetsSemantic proximity Read

A prioritized medium-throughput screen identifies FGF4, FGF5, FGF8F, FGF19 and FGF21 as protective factors for human stem cell derived insulin secreting beta cellsSemantic proximity Read

Reduced Expression of Chl1 gene Impairs Insulin Secretion by Down-Regulating the Expression of Key Molecules of β-cell FunctionSemantic proximity Read

UPLC-ESI-MS based lipidomics revealed novel biomarkers in insulin receptor knockdown induced type 2 diabetes model of DrosophilaSemantic proximity Read

A High-Throughput Assay for the Pancreatic Islet Beta-Cell Potassium Channel: Use in the Pharmacological Characterization of Insulin Secretagogues Identified from Phenotypic Screening.Semantic proximity Read

Effect of treatment with GLP-1R agonists on the urinary peptidome of T2DM patientsSemantic proximity Read

Target deconvolution of an insulin hypersecretion-inducer acting through VDAC1 with a distinct transcriptomic signature in beta-cellsSemantic proximity Read

Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonistsSemantic proximity Read