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Ghrelin suppresses insulin secretion in human islets and type 2 diabetes patients have diminished islet ghrelin cell number and lower plasma ghrelin levels.

Molecular and cellular endocrinology - 1 Jul 2020

Lindqvist A, Shcherbina L, Prasad R B, Miskelly M G, Abels M, Martínez-Lopéz J A, Fred R G, Nergård B J, Hedenbro J, Groop L, Hjerling-Leffler J, Wierup N

Abstract excerpt

It is not known how ghrelin affects insulin secretion in human islets from patients with type 2 diabetes (T2D) or whether islet ghrelin expression or circulating ghrelin levels are altered in T2D. Here we sought out to identify the effect of ghrelin on insulin secretion in human islets and the impact of T2D on circulating ghrelin levels and on islet ghrelin cells. The effect of ghrelin on insulin secretion was...

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PMID: 32371087
DOI: 10.1016/j.mce.2020.110835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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