Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h

5 Jul 2024

Abstract excerpt

Abstract Aims/hypothesis Disruption of pancreatic islet function and glucose homeostasis can lead to the development of sustained hyperglycaemia, beta cell glucotoxicity and subsequently type 2 diabetes. In this study, we explored the effects of in vitro hyperglycaemic conditions on human pancreatic islet gene expression across 24 h in six pancreatic cell types: alpha; beta; gamma; delta; ductal; and acinar. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Pancreatic function and diabetes
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38967666
DOI: 10.1007/s00125-024-06214-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 hPMID 38967666Read ↗

Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 hoursSemantic proximity Read ↗

Identification of unique cell type responses in pancreatic islets to stressSemantic proximity Read ↗

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 DiabetesSemantic proximity Read ↗

Integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D-associated genes and regulatory signals.Semantic proximity Read ↗

Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes riskSemantic proximity Read ↗

Integrated meta-analysis of public human pancreatic single-cell transcriptomes reveals distinct beta-cell state trajectories across aging and diabetesSemantic proximity Read ↗

An integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D associated genes and regulatory signalsSemantic proximity Read ↗

Calcium-dependent transcriptional profiles of human pancreatic islet cells reveal functional diversity in islet subpopulationsSemantic proximity Read ↗

Single-cell gene expression and chromatin accessibility profiling of human pancreatic islets at basal and stimulatory conditions nominates mechanisms of type 1 diabetes genetic riskSemantic proximity Read ↗

Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key β-Cell-Specific Disease GenesSemantic proximity Read ↗

Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profilesSemantic proximity Read ↗

An Integrated Map of Cell Type–Specific Gene Expression in Pancreatic IsletsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.