Article

A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function

2020-04-29

Abstract excerpt

Type 2 diabetes (T2D) is a global pandemic with a strong genetic component, but most causal genes influencing the disease risk remain unknown. It is clear, however, that the pancreatic beta cell is central to T2D pathogenesis. In vitro gene-knockout (KO) models to study T2D risk genes have so far focused on rodent beta cells. However, there are important structural and functional differences between rodent and hu...

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Literature Corpus work: 34e9891f-1ab6-5b08-ac96-0fc439753db2
DOI: 10.12688/wellcomeopenres.15447.2

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