Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Initial Characterization of 12 New Subtypes and Variants of Type V CRISPR Systems.

The CRISPR journal - 1 Apr 2025

Tordoff Jesse, Alfonse Lauren E, Makarova Kira S, Ornstein Alexa, Garrity Anthony J, Yan Winston X, Scott David A, Koonin Eugene V, Cheng David R

Abstract excerpt

Type V CRISPR systems are highly diverse in sequence, mechanism, and function. Although recent efforts have greatly expanded our understanding of their evolution, the diversity of type V systems remains to be completely explored, and many clades have not been experimentally characterized. In this work, we mined metagenomic databases to identify three new subtypes and nine new variants of Cas12, the effector of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteriophages
Share to Clustered Regularly Interspaced Short Palindromic Repeats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CRISPR-Associated Proteins

Share to CRISPR-Cas Systems

Share to Gene Editing

Share to PAM gene

Share to Genetic Variation

Share to Prophages

Source

Open in PubMed Open full text

Identifiers

PMID: 40163416
DOI: 10.1089/crispr.2024.0100
PMCID: PMC12171694

Genes

PAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Initial Characterization of 12 New Subtypes and Variants of Type V CRISPR Systems.PMID 40163416Read ↗

Discovery of Diverse CRISPR-Cas Systems and Expansion of the Genome Engineering ToolboxSemantic proximity Read ↗

Expanding the CRISPR toolbox by engineering Cas12a orthologs of metagenomic discoverySemantic proximity Read ↗

Novel miniature CRISPR–Cas13 systems from uncultivated microbes effective in degrading SARS-CoV-2 sequences and influenza virusesSemantic proximity Read ↗

Metagenomic discovery of novel CRISPR-Cas13 systemsSemantic proximity Read ↗

CRISPRimmunity: an interactive web server for CRISPR-associated Important Molecular events and Modulators Used in geNome edIting Tool identifYingSemantic proximity Read ↗

PAM recognition by miniature CRISPR–Cas12f nucleases triggers programmable double-stranded DNA target cleavageSemantic proximity Read ↗

Harnessing Non-Canonical crRNAs to Improve Functionality of Cas12a OrthologsSemantic proximity Read ↗

Evolutionary and mechanistic diversity of Type I-F CRISPR-associated transposons.Semantic proximity Read ↗

Directed evolution expands CRISPR-Cas12a genome editing capacitySemantic proximity Read ↗

Diversity, classification and evolution of CRISPR-Cas systems.Semantic proximity Read ↗

Characterization of Cas12a nucleases reveals diverse PAM profiles between closely-related orthologs.Semantic proximity Read ↗

CRISPR-Cas Systems: A Functional Perspective and InnovationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.