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Article

Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3

30 Oct 1998

Abstract excerpt

Vascular endothelial growth factor (VEGF) is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGF-C stimulates the growth of lymphatic vessels through its specific lymphatic endothelial receptor VEGFR-3. Here it is shown that targeted inactivation of the gene encoding VEGFR-3 resulted in defective blood vessel development in early mouse embryos....

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Share to Angiogenesis and VEGF in Cancer
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PMID: 9794766
DOI: 10.1126/science.282.5390.946

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