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Article

VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling.

Circulation research - 28 Apr 2017

Heinolainen Krista, Karaman Sinem, D'Amico Gabriela, Tammela Tuomas, Sormunen Raija, Eklund Lauri, Alitalo Kari, Zarkada Georgia

Abstract excerpt

RATIONALE: Vascular endothelial growth factor (VEGF) is the main driver of angiogenesis and vascular permeability via VEGF receptor 2 (VEGFR2), whereas lymphangiogenesis signals are transduced by VEGFC/D via VEGFR3. VEGFR3 also regulates sprouting angiogenesis and blood vessel growth, but to what extent VEGFR3 signaling controls blood vessel permeability remains unknown. OBJECTIVE: To investigate the role of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Human Umbilical Vein Endothelial Cells

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Share to Vascular Endothelial Growth Factor Receptor-2

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Source

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Identifiers

PMID: 28298294
DOI: 10.1161/CIRCRESAHA.116.310477
PMCID: PMC6959003

Genes

VEGFC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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