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Article

Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms.

Nature communications - 3 Apr 2018

Zhang Yan, Ulvmar Maria H, Stanczuk Lukas, Martinez-Corral Ines, Frye Maike, Alitalo Kari, Mäkinen Taija

Abstract excerpt

Incomplete delivery to the target cells is an obstacle for successful gene therapy approaches. Here we show unexpected effects of incomplete targeting, by demonstrating how heterogeneous inhibition of a growth promoting signaling pathway promotes tissue hyperplasia. We studied the function of the lymphangiogenic VEGFR3 receptor during embryonic and post-natal development. Inducible genetic deletion of Vegfr3 in...

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Share to Endothelial Cells
Share to Endothelium, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Image Processing, Computer-Assisted

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Share to Vascular Endothelial Growth Factor Receptor-3

Source

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Identifiers

PMID: 29615616
DOI: 10.1038/s41467-018-03692-0
PMCID: PMC5882855

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