Article
VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature.
American journal of physiology. Heart and circulatory physiology - 1 Feb 2006
Kamba Tomomi, Tam Betty Y Y, Hashizume Hiroya, Haskell Amy, Sennino Barbara, Mancuso Michael R, Norberg Scott M, O'Brien Shaun M, Davis Rachel B, Gowen Lori C, Anderson Keith D, Thurston Gavin, Joho Shuji, Springer Matthew L, Kuo Calvin J, McDonald Donald M
Abstract excerpt
Unlike during development, blood vessels in the adult are generally thought not to require VEGF for normal function. However, VEGF is a survival factor for many tumor vessels, and there are clues that some normal blood vessels may also depend on VEGF. In this study, we sought to identify which, if any, vascular beds in adult mice depend on VEGF for survival. Mice were treated with a small-molecule VEGF receptor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.