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The Molecular and Enzyme Kinetic Basis for Altered Activity of Three Cytochrome P450 2C19 Variants Found in the Chinese Population.

Current molecular pharmacology - 1 Jan 2020

Dong Amelia Nathania, Ahemad Nafees, Pan Yan, Palanisamy Uma Devi, Yiap Beow Chin, Ong Chin Eng

Abstract excerpt

BACKGROUND: There is a large inter-individual variation in cytochrome P450 2C19 (CYP2C19) activity. The variability can be caused by the genetic polymorphism of CYP2C19 gene. This study aimed to investigate the molecular and kinetics basis for activity changes in three alleles including CYP2C19*23, CYP2C19*24 and CYP2C19*25found in the Chinese population. METHODS: The three variants expressed by bacteria were...

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Identifiers

PMID: 31713493
DOI: 10.2174/1874467212666191111110429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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