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Article

Human CYP2C8: structure, substrate specificity, inhibitor selectivity, inducers and polymorphisms.

Current drug metabolism - 1 Nov 2009

Lai Xin-Sheng, Yang Li-Ping, Li Xiao-Tian, Liu Jun-Ping, Zhou Zhi-Wei, Zhou Shu-Feng

Abstract excerpt

Human CYP2C8 is a key member of the CYP2C family and metabolizes more than 60 clinical drugs. A number of active site residues in CYP2C8 have been identified based on homology modeling and site-directed mutagenesis studies. In the structure of CYP2C8, the large active site cavity exhibits a trifurcated topology that approximates a T or Y shape, which is consistent with the finding that CYP2C8 can efficiently...

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PMID: 20214592
DOI: 10.2174/138920009790711832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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