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Article

The "LLQY" Motif on SARS-CoV-2 Spike Protein Affects S Incorporation into Virus Particles.

Journal of virology - 23 Mar 2022

Du Shouwen, Xu Wang, Wang Yuhang, Li Letian, Hao Pengfei, Tian Mingyao, Wang Maopeng, Li Tiyuan, Wu Shipin, Liu Quan, Bai Jieying, Qu Xiaoyun, Jin Ningyi, Zhou Boping, Liao Ming, Li Chang

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein mediates viral entry and membrane fusion. Its cleavage at S1/S2 and S2' sites during the biosynthesis in virus producer cells and viral entry are critical for viral infection and transmission. In contrast, the biological significance of the junction region between both cleavage sites for S protein synthesis and function is less...

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Identifiers

PMID: 35045269
DOI: 10.1128/jvi.01897-21
PMCID: PMC8941915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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