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Structure, Function, and Evolution of Coronavirus Spike Proteins

30 Aug 2016

Abstract excerpt

The coronavirus spike protein is a multifunctional molecular machine that mediates coronavirus entry into host cells. It first binds to a receptor on the host cell surface through its S1 subunit and then fuses viral and host membranes through its S2 subunit. Two domains in S1 from different coronaviruses recognize a variety of host receptors, leading to viral attachment. The spike protein exists in two...

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PMID: 27578435
DOI: 10.1146/annurev-virology-110615-042301

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