Article
Aberrant Compartment Formation by HSPB2 Mislocalizes Lamin A and Compromises Nuclear Integrity and Function.
Cell reports - 29 Aug 2017
Morelli Federica F, Verbeek Dineke S, Bertacchini Jessika, Vinet Jonathan, Mediani Laura, Marmiroli Sandra, Cenacchi Giovanna, Nasi Milena, De Biasi Sara, Brunsting Jeanette F, Lammerding Jan, Pegoraro Elena, Angelini Corrado, Tupler Rossella, Alberti Simon, Carra Serena
Abstract excerpt
Small heat shock proteins (HSPBs) contain intrinsically disordered regions (IDRs), but the functions of these IDRs are still unknown. Here, we report that, in mammalian cells, HSPB2 phase separates to form nuclear compartments with liquid-like properties. We show that phase separation requires the disordered C-terminal domain of HSPB2. We further demonstrate that, in differentiating myoblasts, nuclear HSPB2...
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