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DNA damage‐induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation

15 Jan 2023

Abstract excerpt

Cellular senescence is linked to a wide range of age-related diseases and can be triggered by a variety of stresses, including DNA damage. A variety of genotoxic stressors, such as anti-cancer drugs, cause DNA double-strand breaks (DSBs), which trigger the accumulation of the tumour suppressor protein p53 in the nucleus. Cellular stresses stabilize and activate the p53 signalling pathway, which regulates various...

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PMID: 36642815
DOI: 10.1111/cpr.13398

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