Article
Characterization of RNF43 frameshift mutations that drive Wnt ligand- and R-spondin-dependent colon cancer.
The Journal of pathology - 1 May 2022
Yamamoto Daisuke, Oshima Hiroko, Wang Dong, Takeda Haruna, Kita Kenji, Lei Xuelian, Nakayama Mizuho, Murakami Kazuhiro, Ohama Takashi, Takemura Hirofumi, Toyota Mutsumi, Suzuki Hiromu, Inaki Noriyuki, Oshima Masanobu
Abstract excerpt
Loss-of-function mutations in RNF43 induce activation of Wnt ligand-dependent Wnt/β-catenin signaling through stabilization of the Frizzled receptor, which is often found in microsatellite instability (MSI)-type colorectal cancer (CRC) that develops from sessile serrated adenomas. However, the mechanism underlying how RNF43 mutations promote tumorigenesis remains poorly understood. In this study, we established...
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