Article
RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis.
Oncotarget - 25 Oct 2016
Bond Catherine E, McKeone Diane M, Kalimutho Murugan, Bettington Mark L, Pearson Sally-Ann, Dumenil Troy D, Wockner Leesa F, Burge Matthew, Leggett Barbara A, Whitehall Vicki L J
Abstract excerpt
Serrated pathway colorectal cancers (CRCs) are characterised by a BRAF mutation and half display microsatellite instability (MSI). The Wnt pathway is commonly upregulated in conventional CRC through APC mutation. By contrast, serrated cancers do not mutate APC. We investigated mutation of the ubiquitin ligases RNF43 and ZNRF3 as alternate mechanism of altering the Wnt signal in serrated colorectal neoplasia....
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