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Article

RNF43 mutation analysis in serrated polyposis, sporadic serrated polyps and Lynch syndrome polyps.

Histopathology - 1 Apr 2021

van Herwaarden Yasmijn J, Koggel Lieke M, Simmer Femke, Vink-Börger Elisa M, Dura Polat, Meijer Gerrit A, Nagengast Fokko M, Hoogerbrugge Nicoline, Bisseling Tanya M, Nagtegaal Iris D

Abstract excerpt

AIMS: RNF43 is suggested to be involved in the serrated pathway towards colorectal cancer and encodes a transmembrane Ring-type E3 ubiquitin ligase that negatively regulates the Wnt pathway. This study aimed to elucidate the role of RNF43 gene variants in serrated polyposis syndrome (SPS) and serrated polyps. METHODS AND RESULTS: Three cohorts were tested. The first cohort included germline DNA of 26 SPS patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis

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Source

Open in PubMed Open full text

Identifiers

PMID: 33098683
DOI: 10.1111/his.14286
PMCID: PMC8048817

Genes

RNF43

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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