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Article

RNF43 and ZNRF3: Versatile regulators at the membrane and their role in cancer.

Biochimica et biophysica acta. Reviews on cancer - 1 Nov 2024

Li Shanshan, Niu Jiahui, Smits Ron

Abstract excerpt

RNF43 and ZNRF3 are recognized as important regulators of Wnt/β-catenin signaling by maintaining Wnt-receptors at minimal essential levels. In various cancer types, particularly gastrointestinal tumors, mutations in these genes lead to abnormal Wnt-dependent activation of β-catenin signaling. However, recent findings implicate RNF43/ZNRF3 also in the regulation of other tumor-related proteins, including EGFR,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39551397
DOI: 10.1016/j.bbcan.2024.189217

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