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Article

Channelopathy-causing mutations in the S45A/S45B and HA/HB helices of KCa2.3 and KCa3.1 channels alter their apparent Ca2+ sensitivity.

Cell calcium - 1 Mar 2022

Orfali Razan, Nam Young-Woo, Nguyen Hai Minh, Rahman Mohammad Asikur, Yang Grace, Cui Meng, Wulff Heike, Zhang Miao

Abstract excerpt

Small- and intermediate-conductance Ca2+-activated potassium (KCa2.x and KCa3.1, also called SK and IK) channels are activated exclusively by a Ca2+-calmodulin gating mechanism. Wild-type KCa2.3 channels have a Ca2+ EC50 value of ∼0.3 μM, while the apparent Ca2+ sensitivity of wild-type KCa3.1 channels is ∼0.27 μM. Heterozygous genetic mutations of KCa2.3 channels have been associated with Zimmermann-Laband...

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Identifiers

PMID: 35030515
DOI: 10.1016/j.ceca.2022.102538
PMCID: PMC8844225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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