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Article

Contribution of the KCa3.1 channel-calmodulin interactions to the regulation of the KCa3.1 gating process.

The Journal of general physiology - 1 Jul 2013

Morales Patricia, Garneau Line, Klein Hélène, Lavoie Marie-France, Parent Lucie, Sauvé Rémy

Abstract excerpt

The Ca(2+)-activated potassium channel of intermediate conductance, KCa3.1, is now emerging as a therapeutic target for a large variety of health disorders. The Ca(2+) sensitivity of KCa3.1 is conferred by the Ca(2+)-binding protein calmodulin (CaM), with the CaM C-lobe constitutively bound to an intracellular domain of the channel C terminus. It was proposed on the basis of the crystal structure obtained for the...

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Identifiers

PMID: 23797421
DOI: 10.1085/jgp.201210933
PMCID: PMC3691446

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Source receipt: pubmed, retrieved 7 Sept 2026.

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