The ataxia-linked E1081Q mutation affects the sub-plasma membrane Ca2+-microdomains by tuning PMCA3 activity.

doi:10.1038/s41419-022-05300-y

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The ataxia-linked E1081Q mutation affects the sub-plasma membrane Ca2+-microdomains by tuning PMCA3 activity.

Cell death & disease - 7 Oct 2022

Vallese Francesca, Maso Lorenzo, Giamogante Flavia, Poggio Elena, Barazzuol Lucia, Salmaso Andrea, Lopreiato Raffaele, Cendron Laura, Navazio Lorella, Zanni Ginevra, Weber Yvonne, Kovacevic-Preradovic Tatjana, Keren Boris, Torraco Alessandra, Carrozzo Rosalba, Peretto Francesco, Peggion Caterina, Ferro Stefania, Marin Oriano, Zanotti Giuseppe, Calì Tito, Brini Marisa, Carafoli Ernesto

Abstract excerpt

Calcium concentration must be finely tuned in all eukaryotic cells to ensure the correct performance of its signalling function. Neuronal activity is exquisitely dependent on the control of Ca2+ homeostasis: its alterations ultimately play a pivotal role in the origin and progression of many neurodegenerative processes. A complex toolkit of Ca2+ pumps and exchangers maintains the fluctuation of cytosolic Ca2+...

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PMID: 36207321
DOI: 10.1038/s41419-022-05300-y
PMCID: PMC9546857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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