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Article

Hydrophobic interactions between the HA helix and S4-S5 linker modulate apparent Ca2+ sensitivity of SK2 channels.

Acta physiologica (Oxford, England) - 1 Jan 2021

Nam Young-Woo, Cui Meng, Orfali Razan, Viegas Adam, Nguyen Misa, Mohammed Eman H M, Zoghebi Khalid A, Rahighi Simin, Parang Keykavous, Zhang Miao

Abstract excerpt

AIM: Small-conductance Ca2+ -activated potassium (SK) channels are activated exclusively by increases in intracellular Ca2+ that binds to calmodulin constitutively associated with the channel. Wild-type SK2 channels are activated by Ca2+ with an EC50 value of ~0.3 μmol/L. Here, we investigate hydrophobic interactions between the HA helix and the S4-S5 linker as a major determinant of channel apparent Ca2+...

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Identifiers

PMID: 32865319
DOI: 10.1111/apha.13552
PMCID: PMC7736289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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