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Article

Apolipoprotein E e4 allele affects risk of hyperhomocysteinemia in the elderly.

The American journal of clinical nutrition - 1 Dec 2006

Ravaglia Giovanni, Forti Paola, Maioli Fabiola, Chiappelli Martina, Montesi Fausta, Bianchin Marisa, Licastro Federico, Patterson Christopher

Abstract excerpt

BACKGROUND: Apolipoprotein E (APOE) plays a central role in VLDL metabolism. Both APOE e4 allele (APOE4) and C-reactive protein (CRP) are associated with greater risk of dementia and vascular disease, but APOE4 carriers have lower blood concentrations of CRP than do noncarriers, possibly through a mechanism favoring the clearance of the CRP VLDL-bound fraction. Homocysteine, another risk factor for vascular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17158432
DOI: 10.1093/ajcn/84.6.1473

Genes

CRP
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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