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Article

Spatiotemporal expression of NRAS and occurrence of giant congenital melanocytic nevi.

Experimental dermatology - 1 Apr 2022

Aimaier Rehanguli, Chung Manhon, Zhu Hainan, Yu Qingxiong

Abstract excerpt

The mechanism underlying giant congenital melanocytic nevus (GCMN) formation is not fully understood. According to recent research, NRAS gene mutation is the main driving factor in GCMN. Melanocytic precursor cells proliferate during the embryonic stage after acquiring NRAS mutations. However, why GCMN undergoes intense proliferation in the embryonic stage and then stops postnatally remains unknown. The current...

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PMID: 35020224
DOI: 10.1111/exd.14527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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