Article
Genotypic and gene expression studies in congenital melanocytic nevi: insight into initial steps of melanotumorigenesis.
The Journal of investigative dermatology - 1 Jan 2009
Dessars Barbara, De Raeve Linda E, Morandini Renato, Lefort Anne, El Housni Hakim, Ghanem Ghanem E, Van den Eynde Benoît J, Ma Wenbin, Roseeuw Diane, Vassart Gilbert, Libert Frédérick, Heimann Pierre
Abstract excerpt
Large congenital melanocytic nevi (CMNs) are said to have a higher propensity to malignant transformation compared with acquired nevi. Thus, they represent a good model for studying initial steps of melanotumorigenesis. We have performed genotypic (karyotype, fluorescence in situ hybridization, and mutational analyses) and differential expression studies on a large cohort of medium (n=3) and large (n=24) CMN....
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