Amplification of Mutant NRAS in Melanocytic Tumors With Features of Spitz Tumors.

doi:10.1016/j.modpat.2024.100469

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Article

Amplification of Mutant NRAS in Melanocytic Tumors With Features of Spitz Tumors.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2024

Cloutier Jeffrey M, Wang Meng, Vemula Swapna S, Mirza Sonia, Weier Jingly, Aquino Jamie D, McCalmont Timothy H, LeBoit Philip E, Bastian Boris C, Yeh Iwei

Abstract excerpt

NRAS activating mutations are prevalent in melanocytic neoplasia, occurring in a subset of common acquired melanocytic nevi and ∼30% of cutaneous melanomas. In this study, we described a cohort of 7 distinctive melanocytic tumors characterized by activating point mutations in codon 61 of NRAS with amplification of the mutant NRAS allele and shared clinicopathologic features. These tumors occurred predominantly in...

Topics

Humans
GTP Phosphohydrolases
Skin Neoplasms
Male
Female
Middle Aged
Membrane Proteins
Adult
Adolescent
Child
Young Adult

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nevus, Epithelioid and Spindle Cell

Melanoma

Gene Amplification

Melanocytes

Mutation

Nevus, Pigmented

Point Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 38467248
DOI: 10.1016/j.modpat.2024.100469
PMCID: PMC12970005

Genes

NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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