Amplification of mutated NRAS leading to congenital melanoma in neurocutaneous melanocytosis.

doi:10.1097/CMR.0000000000000188

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Article

Amplification of mutated NRAS leading to congenital melanoma in neurocutaneous melanocytosis.

Melanoma research - 1 Oct 2015

Salgado Cláudia M, Basu Dipanjan, Nikiforova Marina, Hamilton Ronald L, Gehris Robin, Jakacki Regina, Panigrahy Ashok, Yatsenko Svetlana, Reyes-Múgica Miguel

Abstract excerpt

The mechanisms behind malignant progression in patients with giant nevi are largely unknown. Here, we aim to describe novel genetic findings and explain possible mechanisms resulting in the most severe form of neurocutaneous melanocytosis. Detailed histological (biopsy and post-mortem) studies, tissue culture, and high-resolution cytogenetic analysis, including chromosome and array comparative genomic...

Topics

Autopsy
Biopsy
Comparative Genomic Hybridization
Fatal Outcome
GTP Phosphohydrolases
Gene Amplification
Humans
Infant
Male
Melanocytes
Melanoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Melanosis

Membrane Proteins

Mutation

Neurocutaneous Syndromes

Nevus, Pigmented

Skin Neoplasms

Source

Open in PubMed

Identifiers

PMID: 26266759
DOI: 10.1097/CMR.0000000000000188

Genes

NRAS
KDR
KIT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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